In the field of organic chemistry, scientists are always looking out for new types of reactions to unlock synthesis routes for challenging compounds. Most of the progress that we have witnessed in pharmaceutics and agrochemicals over the past few decades can be traced back to the discovery of novel practical reaction pathways. Such pathways often involve the selective replacement of a functional group with another, the formation of aromatic rings, or the strategic cleaving of parts of a molecule. But what about the rearrangement of existing functional groups within a molecule?